MBL oligomer deficient serum, B/B genotype
Human serum
Cat.No. SER 102
Preparation: Frozen, undiluted human serum
Content: Mannan-binding lectin (MBL), <1 arbitrary unit (AU) oligomer per mL
Storage: At -20°C
Stability: 2 years
Human MBL1 is an opsonin, which activates the complement system2 on binding to microbial polysaccharides. Plasma concentrations of normally oligomerized MBL range from 0 to 7000 ng/ml and may be below 50 ng/ml in up to 12% of healthy Caucasian blood donors. Low plasma concentrations may be associated with an inherited opsonin defect3. MBL from donors of B/B genotype is poorly oligomerized and gives low readings in MBL assays selective for oligomerized MBL.
The serum was tested negative for HBsAg and for antibodies against HIV 1, HIV-2 and HCV. Blood from a healthy donor (MBL genotype B/B without promoter defects) was collected in flasks without anticoagulant and allowed to clot. Serum was collected after centrifugation and pooled. After mixing, 1-ml aliquots of the serum was pipetted into 1-ml cryotubes. The material was frozen at -20°C.
Suitable as a null reading standard when testing MBL levels
