Anti-Amodiaquine
Mouse monoclonal antibody
Cat.No. HYB 320-04
Preparation: Protein-A/G purified
Content: Available in 200 μL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Solvent: 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage: 4-8ºC without exposure to light. No precautions necessary during handling.
Amodiaquine is an antimalarial drug with effects very similar to those of chloroquine. Amodiaquine has been widely used to treat malaria. Due to reports of fatal adverse drug reactions, discontinuation or modification of its use has been suggested.
Amodiaquine is a hapten of molecular weight 267.3 g/mol.
4-amino-2(diethylaminomethyl)phenol a preparation of a carrier protein adsorbed onto aluminum hydroxide gel
HYB 320-04 is specific for the non-quinoline sidechain of amodiaquine. HYB 320-04 can be used for quantitation of amodiaquine in human serum or plasma with a detection limit of app. 2 ng/ml.
HYB 320-04 is specific for the non-quinoline sidechain of amodiaquine
HYB 320-04 reacts with amodiaquine and is able to distinguish from other antimalarial drugs. Cross-reactivity towards desethylchloroquine is app. 1%. Cross-reactivity towards desethylamodiaquine has not been tested.
| Method | Usability | References |
| ELISA | Yes | |
| Immunoblotting | Not determined | |
| Immunohistochemistry | Not determined |
1. Rowell V, Rowell FJ, Baker A, Laurie D, Sidki AM (1988) A specific ELISA method for determining chloroquine in urine or dried blood spots. Bull World Health Organ 66:211-217.
2. Shenton FC, Bots M, Menon A, Eggelte TA, de Wit M, Greenwood BM (1988) An ELISA test for detecting chloroquine in urine. Trans R Soc Trop Med Hyg 82:216-220.
3. Escande C, Chevalier P, Verdier F, Bourdon R (1990) Sensitive radioimmunoassay and enzyme-linked immunosorbent assay for the simultaneous determination of chloroquine and its metabolites in biological fluids. J Pharm Sci 79:23-27.
